Mark Tommerdahl - corticalmetrics insights (Page 3)

Measuring Neuroinflammation

July 04, 2018

The Timing Perception measure (or Duration Discrimination) comes from the test that asks you “which stimulus lasted longer?”. This score is useful on its own, but you can gain even more insight into your brain health by comparing it to your Duration Discrimination with confound score. The difference between these two scores is based on a brain illusion - a mistake that your brain makes when comparing two sensations. But don't worry - if your brain is making this mistake, it means that it's healthy!

How the illusion is created

Aging and brain plasticity: what causes the decline?

June 29, 2018

I’ve been in the research field for close to 40 years now (easily 40 if you count my years as an undergraduate biology major, when I was probably more interested in non-academic pursuits, but that is another story), and throughout that tenure, a question that has bothered people – as well as researchers – is why do people age at different rates? Why do some people age gracefully into their late 90s and others struggle through their 60s? As we began to do translational research (i.e., that brand of research

Fractal patterns in the brain

June 27, 2018

Why the Brain Gauge can detect even the smallest neurological changes

One of the chapters of my dissertation discussed the functional organization of mini-columns - the brain's smallest functional groups of neurons. Each mini-column is made up of a vertical array that runs from Layer 1 (outermost cells) to Layer 6 (innermost cells) in the cortex. Though these groupings can be difficult to study - a typical minicolumn is about 1/5 the thickness of a human hair - they can give crucial insight into the overall organization of the

What is the overall corticalmetric score?

June 21, 2018

If you are a Brain Gauge user, you've probably noticed the overall corticalmetric score. This comprehensive measure is calculated from all the tests that were taken in a single test session. If that is a sufficint explanation, then read no further.

When we first started developing cortical metrics – all the different measures collected by the Brain Gauge (and also the name of the company... we realize that can be confusing!) – we wanted to create a unique metric that could summarize the brain profile of each individual. We believe that it

Autism, GABA and the Brain Gauge: the history of our scientific efforts in the field.

June 15, 2018

The Brain Gauge methods predicted GABA deficits in autism that were later validated with medical imaging

After having many discussions with people who are interested in the Brain Gauge technology, I became increasingly aware that a vast majority assume the Brain Gauge was designed exclusively for assessing traumatic brain injury (TBI) and concussion. Although we have received support from the Office of Naval Research for the development of the Brain Gauge as a standardized concussion tool, the development of the device began as a means for studying alterations in brain

Alzheimer’s and Diabetes: Cause or Effect?

June 13, 2018

Alzheimer’s is often called “diabetes type 3” because there appears to be a correlation between the two disorders.

After first identifying amyloid β plaques and tau tangles in the brain of a deceased patient in the early 1900’s, Alois Alzheimer was careful to not infer that these structures had caused the dementia in the patient. Until recently, most of the research (at least by drug companies) has been aimed at finding ways to reverse the accumulation, or at least stop the spread of these structures. While drugs have

The Timing Perception Measure

June 09, 2018

Timing perception is derived from your duration discrimination task. This is the test that asks “Which stimulus lasted longer?” The first trial of the task (during training) delivers a 650 msec duration stimulus to one finger and subsequently a 500 msec duration stimulus to the other (a 150 msec difference). Each time the person taking the test identifies the finger that received the longer stimulus correctly, the difference between the two durations on the next trial is reduced. Most people track down to a difference limen of 35-60 msec, and

Pain – does anyone know how to treat it?

June 06, 2018

Or maybe a better question is – Did anyone ever successfully treat it?

One of the unique things about the somatosensory system that separates it from the other sensory modalities is that there are pain receptors in the skin that project to the somatosensory cortex. All of the painful stimuli we encounter is modulated through the sense of touch. This has been well known for decades, if not centuries, and this concept did not escape medical practitioners - the idea ofremoving this part of the brain to eliminate pain surfaced in

Can HRV be used to monitor brain functions like the Brain Gauge?

June 04, 2018

Many heart medications that improve HRV have a negative impact on brain health that can be measured with the Brain Gauge.

Several people have asked us how heart rate variability (HRV) compares to the Brain Gauge. The question we keep getting is: "Is the HRV measure from my smartwatch as good of an indicator of brain health as the Brain Gauge measures?"

The short answer to this question is no, HRV and Brain Gauge measure completely different things. Heart rate variability gives a measure of the autonomic nervous

The Accuracy Measure

May 31, 2018

Lateral inhibition: using amplitude discrimination to probe the balance between excitation and inhibition
Lateral inhibition is the brain's way of improving contrast between adjacent or near-adjacent cortical areas. In the 1960s, Nobel prize winner Georg Von Bekesy postulated the idea of lateral inhibition. The basic idea was that when you deliver a stimulus, brain activity will be correlated with the stimulus site, and the surrounding areas will be inhibited or turned off. Long story short, Von Bekesy’s predictions, which were based on sensory testing, turned out to be true.